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You are here:Home-Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Yes-associated Protein (YAP)-TT-10
TT-10

Chemical Structure TT-10

CAS No.: 2230640-94-3

TT-10(YAP-TEAD activator TT-10)

Catalog No.GY10236Research Only, Not for Human Use!

TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes; promoted cardiomyocyte proliferation and simultaneously exerted antioxidant and antiapoptotic effects in vitro via nuclear translocation of YAP, activates YAP-TEADs activity and the Wnt/β-Catenin signaling pathway; ameliorates cardiac dysfunction, decreases ROS and DNA aamage and apoptosis after myocardial infarction (MI) in mice.

Physicochemical Properties

M.Wt 283.339
Formula C11H10FN3OS2
CAS No. 2230640-94-3
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

(2-(allylamino)-4-aminothiazol-5-yl)(5-fluorothiophen-2-yl)methanone

Clinical Information


References

1. Hara H, et al. JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653.

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