5 alpha Reductase
5 alpha Reductase (5α-reductases), also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism, and prostate cancer.
||Dutasteride (GG745) is a potent inhibitor of both 5 alpha-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT.
||Epristeride is a novel 5α-reductase inhibor.
||Finasteride (acetate) is an orally active testosterone 5-alpha-reductase inhibitor.