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    Bcl-2 Family

    Bcl-2 is a family of evolutionarily related proteins. These proteins govern mitochondrial outer membrane permeabilization (MOMP) and can be either pro-apoptotic (Bax, Bad, Bak and Bok among others) or anti-apoptotic (including Bcl-2 proper, Bcl-xL, and Bcl-w, among an assortment of others). There are a total of 25 genes in the Bcl-2 family known to date. Human genes encoding proteins that belong to this family include: Bak1, Bax, Bal-2, Bok, Mcl-1.

    Products

    Catalog No. Name Description
    GY05022 New (-) BI97D6 (-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively.
    GY01020 Special Navitoclax (ABT-263) Navitoclax is a potent and orally bioavailable Bcl-2 family protein inhibitor that binds with high affinity (Ki < 1 nM) to multiple anti-apoptotic Bcl-2 family proteins including Bcl-xL, Bcl-2 and Bcl-w.
    GY01335 Special A-1331852 A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
    GY01015 Special ABT-199 (Venetoclax) ABT-199 is a highly potent, orally bioavailable and Bcl-2-selective inhibitor with Ki of <0.01 nM.
    GY01537 Special UMI-77 UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.
    GY01255 AT-101 acetic acid AT-101 acetic acid is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
    GY01272 Obatoclax Mesylate Obatoclax is an inhibitor targeting all antiapoptotic BCL-2 with a Ki of appr 220 nM.
    GY01672 Gossypol acetic acid Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
    GY01673 Gossypol Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
    GY01717 Gambogic Acid Gambogic acid is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic acid inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
    GY01866 HA14-1 HA14-1 is a Bcl-2/Bcl-XL antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC50 of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function.
    GY02270 Marinopyrrole A Marinopyrrole A is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM).
    GY02562 WEHI-539 WEHI-539 is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.
    GY02632 BET bromodomain inhibitor BET bromodomain inhibitor is a potent BET inhibitor extracted from patent WO/2015/153871A2, compound example 11.
    GY02764 Pyridoclax Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor with Kd value of 25 nM.
    GY02837 S63845 S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor; binds human MCL1 with a Kd of 0.19 nM.
    GY03009 WEHI-539 HCl WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.
    GY03133 Mcl1-IN-2 Mcl1-IN-2 is an inhibitor of myeloid cell factor 1 (Mcl-1).
    GY03327 MIM1 MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).
    GY03392 Bax inhibitor peptide V5 (BIP-V5) Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
    GY03461 (+)-Apogossypol (+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 µM, respectively.
    GY03502 Mcl1-IN-1 Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC50=2.4 µM).
    GY03679 AT-101 AT-101 is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
    GY03880 FX1 FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 μM.
    GY06383 BI-3802 BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.
    GY06414 S55746 S55746 (BCL201, Servier-1) is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM, 70- 400 fold selectivity over BCL-XL, on significant binding to MCL-1 and BFL-1.
    GY07107 Mcl1-IN-26 A novel potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays
    GY07143 BDA-366 A potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM