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    Dopamine Transporter

    Dopamine Transporter (DAT) is an integral membrane protein that removes dopamine from the synaptic cleft and deposits it into surrounding cells, thus terminating the signal of the neurotransmitter. Dopamine transporter (DAT) controls the spatial and temporal dynamics of dopamine (DA) neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons. Many diseases such as depression, bipolar disorder, Parkinson’s disease, and attention deficit hyperactivity disorder are associated with abnormal DA levels, implicating DAT as a factor in their etiology. Medications used to treat these disorders and many addictive drugs target DAT and enhance dopaminergic signaling by suppressing transmitter reuptake. DAT is regulated by multiple signaling systems, with PKC and ERK being two of the most well-characterized.

    Products

    Catalog No. Name Description
    GY04273 Special GBR 12935 2HCl GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor.
    GY03793 Dasotraline Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50values of 4, 6, and 11 nM, respectively.