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    PTEN

    PTEN (Phosphatase and tensin homologue deleted on chromosome 10), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes. PTEN has a much wider active site cleft enabling it to bind the PtdIns(3,4,5)P3 substrate. a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations.

    Products

    Catalog No. Name Description
    GY01336 Special SF1670 SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor.
    GY02398 β-Glycerol phosphate disodium salt pentahydrate β-Glycerol phosphate disodium salt pentahydrate is a Phosphatase and tensin homolog (PTEN) inhibitor extracted from patent US 20110002877 A1.
    GY03291 VO-Ohpic trihydrate VO-Ohpic trihydrate is an extremely potent inhibitor of PTEN with IC50 of 46±10 nM.