Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa. For example, Nitazoxanide is an antiparasitic medication used to treat diarrhea due to the intestinal parasite Giardia lamblia.
||Milbemycin oxime is a veterinary drug from the group of milbemycins, used as a broad spectrum antiparasitic.
||PF 1022A is a N-methylated cyclooctadepsipeptides (CODPs) with strong anthelmintic properties; acts as an ionophore.
||Hydroxychloroquine sulfate is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling.
||Broxaldine is an antiprotozoal drug.
||RRx-001 is a potent inhibitor of G6PD.
||Nimorazole is a nitroimidazole anti-infective.
||Fluensulfone is a new nematicide for chemical control of plant parasitic nematodes.
||N205 is a novel anti-malaria compound with in vitro IC50 of 1.3 nM against Plasmodium falciparum (3D7).
||An anticestodal agent, fungicide, germicide, and antimicrobial agent.
||FR900098 sodium salt
||FR 900098 is a derivative of fosmidomycin that inhibits DOXP reductoisomerase, demonstrates antimalarial activity with IC50 of 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively.
||A veterinary anthelmintic with known proton ionophore activities.
||A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties.
||Bephenium hydroxynaphthoate is an anthelmintic compound that acts as an activiator of nematode B-type nAChR, is used in the treatment of hookworm infections and ascariasis.
||An antimalarial drug.
||A potent, selective P. falciparum dihydroorotate dehydrogenase (PfDHODH) with IC50 of 53 nM.
||An orally-active, CNS permeable benzoxaborole antiprotozoal agent.
||Tafenoquine succinate (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.
||Tafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.
||A potent, specific malaria bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) inhibitor with IC50 of 330 nM.
||A selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM.
||Antimalarial compound 49c
||Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM.
||A potent, highly selective, long-duration and orally bioavailable malaria DHODH (PfDHODH) inhibitor with IC50 of 0.01 ug/mL.
||An organophosphorus anthelmintic used against nematodes of the abomasum and small intestine in ruminants. .
||A semisynthetic derivative of PF1022A, and novel cyclo-depsipeptide anthelmintic which is efficacious against a variety of gastrointestinal nematodes.
||Ganaplacide (KAF156, GNF-156) is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.
||Cipargamin (KAE609, NITD609) is a fast-acting, potent antimalarial agent that inhibits blood-stage activity in vitro against a panel of culture-adapted P. falciparum strains with IC50 of 0.5-1.4 nM.
||Artefenomel (OZ439) is a novel, next-generation antimalarial ozonide that demonstrates high potentcy against P. falciparum in vitro and P. berghei in vivo (K1/NF54, IC50=2.0/3.2 nM).