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    Toll-like Receptor (TLR)

    Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganism and are involved in sensing endogenous danger signals. TLRs are evolutionarily conserved receptors are homologues of the Drosophila Toll protein, discovered to be important for defense against microbial infection. TLRs recognize highly conserved structural motifs known as pathogen-associated microbial patterns (PAMPs), which are exclusively expressed by microbial pathogens.


    Catalog No. Name Description
    GY01496 Special Motolimod (VTX-2337) Motolimod is a selective Toll-like receptor (TLR) 8 agonist, with EC50 of about 100 nM.
    GY04321 Special Resiquimod Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the levels of cytokines such as TNF-α, IL-6 and IFN-α.
    GY02186 Gardiquimod trifluoroacetate Gardiquimod trifluoroacetate is a specific TLR7 agonist which can also inhibit HIV-1 reverse transcriptase.
    GY03089 Leonurine HCl Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
    GY03514 Atractylenolide I Atractylenolide I is a natural compound extracted from largehead atractylodes rhizome; induce apoptosis and bring about cytotoxicity of human promyeloleukemic HL-60 cells; TLR4-antagonizing agent.
    GY03804 TLR7-IN-1 TLR7-agonist-1 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM.
    GY03865 E6446 2HCl E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
    GY04719 CU-CPT-9b CU-CPT-9b is a nolve TLR8 inhibitor.
    GY05160 Semapimod Semapimod (CNI 1493.
    GY07393 IAXO-102 IAXO-102 is a TLR4 antagonist, inhibits MAPK and p65 NF-kB phosphorylation involved in down regulation of the expression of TLR4 and TLR4 dependent proinflammatory protein. IAXO-102 prevents experimental abdominal aortic aneurysm development.
    GY05246 Semapimod HCl Semapimod (CNI 1493.
    GY05368 CPG-52364 An orally available, small molecule TLR7/8/9 antagonist for the treatment of systemic lupus erythematosus and other autoimmune disorders..
    GY06930 Gardiquimod Gardiquimod is a TLR7 agonist, inducing the activation of NF-B in HEK293 cells expressing human or mouse TLR7.
    GY06931 Gardiquimod HCl Gardiquimod hydrochloride is a TLR7 agonist, inducing the activation of NF-B in HEK293 cells expressing human or mouse TLR7.